ACTH therapy benefits stuttering and autism
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Adrenocorticotropic hormone therapy in patients with nighttime subclinical seizure activity improves their stuttering and autism symptoms alongside EEG parameters.
In a retrospective study a total of 25 patients with attention deficit and hyperactivity (ADHD) or autism spectrum and comorbid stuttering were followed and treated with adrenocorticotropic hormone (ACTH) for electrical status epilepticus in sleep (ESES). Following treatment with ACTH, normalisation of EEG parameters and subclinical epileptiform activity in all the patients was accompanied by a 72% improvement in ADHD or autism symptoms, and 83.8% improvement in stuttering. Twelve of the 25 patients with stuttering showed complete treatment response. The authors noted that the improvement in stuttering had a positive correlation with improvement in ADHD or autism symptoms.
This article is part of Treating Autism Clinical & Research Newsletter: Issue 2
References:
Altunel A, Sever A, & Altunel EÖ. (2017) ACTH has beneficial effects on stuttering in ADHD and ASD patients with ESES: A retrospective study. Brain Dev. Feb;39(2):130-137. doi: 10.1016/j.braindev.2016.09.001.